SABCS 2023: Breast Cancer Pro Portal

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New Drug Approvals for Metastatic Breast Cancer in 2023

Kate Lathrop, MD

17:08 Minutes

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RF01-07 - The efficacy and safety of tinengotinib in patients with advanced or metastatic HR+/HER2-breast cancer or TNBC

Ruth O'Regan, MD

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RF01-01 - SERENA-3: A randomized pre-surgical window of opportunity study assessing dose and duration of camizestrant treatment in post-menopausal women with ER-positive, HER2-negative primary cancer

Ruth O'Regan, MD

4:46 Minutes

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GS01-06 - Advancing evidence of the associations between specific benign breast diagnoses and future breast cancer risk

Hope Rugo, MD

6:55 Minutes

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GS01-10 - HER2CLIMB-02: Randomized, double-blind phase 3 trial of tucatinib and trastuzumab emtansine for previously treated her2-positive metastatic breast cancer

Hope Rugo, MD

8:58 Minutes

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GS01-08 - CDK4/6 inhibition is a potential vulnerability in NF1-depleted ER+ breast cancer

Hope Rugo, MD

5:54 Minutes

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GS01-05 - Pembrolizumab + olaparib vs pembrolizumab + chemotherapy after induction with pembrolizumab + chemotherapy for locally recurrent inoperable or metastatic TNBC: Randomized open-label phase 2 KEYLYNK-009 study

Hope Rugo, MD

9:56 Minutes

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RF01-04 - Final results from the phase 2, open-label FOENIX-MBC2 study: efficacy and safety of futibatinib in adult patients with locally advanced/metastatic HR+/HER2− breast cancer harboring high-level FGFR1 gene amplification

Ruth O'Regan, MD

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RF01-03 - PARSIFAL-LONG: Extended follow-up of hormone receptor-positive/HER2-negative advanced breast cancer patients treated with fulvestrant and palbociclib vs letrozole and palbociclib in the PARSIFAL study

Ruth O'Regan, MD

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RF01-08 - A randomized, open-label phase III trial Evaluating Low-Dose Vs standard-dose Olanzapine with triple Antiemetic therapy for Prevention of highly emetogenic chemotherapy- induced Nausea and vomiting in solid tumors (OLAnzaPiNE)

Ruth O'Regan, MD

05:12 Minutes

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GS01-12 - MONARCH 3: Final overall survival results of abemaciclib plus a nonsteroidal aromatase inhibitor as first-line therapy for HR+, HER2- advanced breast cancer

Hope Rugo, MD

8:09 Minutes

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RF01-02 - A randomized Phase I pre-operative window trial of transdermal endoxifen in women planning mastectomy

Ruth O'Regan, MD

Minutes

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RF01-06 - Efficacy and safety of toripalimab plus metronomic chemotherapy in HER2 negative metastatic breast cancer

Ruth O'Regan, MD

Minutes

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GS01-03 - Adding atezolizumab to adjuvant chemotherapy for stage II and III triple-negative breast cancer is unlikely to improve efficacy:interim analysis of the ALEXANDRA/IMpassion030 phase 3 trial.

Hope Rugo, MD

8:14 Minutes

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GS01-02 - Phase 3 study of neoadjuvant pembrolizumab or placebo plus chemotherapy, followed by adjuvant pembrolizumab or placebo plus endocrine therapy for early-stage high-risk ER+/HER2 - breast cancer: KEYNOTE-756

Hope Rugo, MD

12:45 Minutes

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GS01-01 - Biomarker results in high-risk estrogen receptor positive, human epidermal growth factor receptor 2 negative primary breast cancer following neoadjuvant chemotherapy ± nivolumab: An exploratory analysis of CheckMate 7FL

Hope Rugo, MD

10:47 Minutes

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GS02-04 - Surgical treatment of women with breast cancer and a BRCA1 mutation: an international analysis of the impact of bilateral mastectomy on survival.

Adam Brufsky, MD, PhD

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GS02-06 - Recurrence-free survival following sentinel node-positive breast cancer without completion axillary lymph node dissection – first results from the international randomized SENOMAC trial.

Adam Brufsky, MD, PhD

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GS02-08 - Five-year outcomes of the IDEA trial of endocrine therapy without radiotherapy after breast-conserving surgery for postmenopausal patients age 50-69 with genomically-selected favorable Stage I breast cancer

Adam Brufsky, MD, PhD

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GS02-07 - Loco-regional irradiation in patients with biopsy-proven axillary node involvement at presentation who become pathologically node-negative after neoadjuvant chemotherapy: primary outcomes of NRG Oncology/NSABP B-51/RTOG 1304

Adam Brufsky, MD, PhD

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GS02-01 - Randomized phase 3 study of datopotamab deruxtecan vs chemotherapy for patients with inoperable or metastatic hormone receptor-positive, HER2- breast cancer: efficacy, safety and biomarker results from TROPION-Breast01.

Adam Brufsky, MD, PhD

Minutes

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GS03-07 - Protocol-defined biomarker analysis in the PALLAS (AFT-05) adjuvant trial: Genomic subtype derived from RNA sequencing of HR+/HER2- early breast cancer.

Joseph Sparano

Minutes

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LBO1-03 - Randomized Phase II Study of Neoadjuvant Nivolumab (N) 2 week lead-in followed by 12 weeks of concurrent N+carboplatin plus paclitaxel (CbP) vs concurrent N+CbP in Triple Negative Breast Cancer (TNBC): (BCT1902/IBCSG 61-20 Neo-N)

Kevin Kalinsky, MD, MS, FASCO

Minutes

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GS03-03 - Ribociclib (RIB) + nonsteroidal aromatase inhibitor (NSAI) as adjuvant treatment in patients with HR+/HER2− early breast cancer: final invasive disease–free survival (iDFS) analysis from the NATALEE trial

Joseph Sparano

Minutes

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GS03-01- Magnetic Resonance Imaging and a 12-gene expression assay to optimize local therapy for ductal carcinoma in situ: 5-year clinical outcomes of E4112

Joseph Sparano

Minutes

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LBO1-04 - Primary results from a phase 2a study of zanidatamab (zani) + palbociclib (palbo) + fulvestrant (fulv) in HER2+/HR+ metastatic breast cancer (mBC)

Kevin Kalinsky, MD, MS, FASCO

Minutes

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LBO1-01 - Neoadjuvant pembrolizumab or placebo plus chemotherapy followed by adjuvant pembrolizumab or placebo for early-stage triple-negative breast cancer: Updated event-free survival results from the phase 3 KEYNOTE-522 study

Minutes

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LBO1-02 - Pathologic complete response (pCR) of neoadjuvant therapy with or without atezolizumab in HER2-positive, early high-risk and locally advanced breast cancer: APTneo Michelangelo randomized trial

Kevin Kalinsky, MD, MS, FASCO

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GS03-13 - Phase III study of inavolisib or placebo in combination with palbociclib and fulvestrant in patients with PIK3CA-mutant, hormone receptor-positive, HER2-negative locally advanced or metastatic breast cancer: INAVO120 primary analysis

Kevin Kalinsky, MD, MS, FASCO

Minutes

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GS03-12 - Phase III study of adjuvant ado-trastuzumab emtansine vs trastuzumab for residual invasive HER2-positive early breast cancer after neoadjuvant chemotherapy and HER2-targeted therapy: KATHERINE final IDFS and updated OS analysis

Kevin Kalinsky, MD, MS, FASCO

Minutes

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GS03-06 - Genomic and transcriptomic profiling of primary tumors from patients with HR+, HER2-, node-positive, high-risk early breast cancer in the monarchE trial

Joseph Sparano

Minutes

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Early Breast Cancer

Virginia Kaklamani, MD, DSc

Minutes

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Metastatic Breast Cancer

Virginia Kaklamani, MD, DSc

Minutes

SABCS 2023 Video highlights